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KMID : 0043320110340020211
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Archives of Pharmacal Research
2011 Volume.34 No. 2 p.211 ~ p.215
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Inhibitory effect of glucodistylin from the bark of Quercus acutissima on human recombinant aldose reductase and sorbitol accumulation
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Lee Yeon-Sil
Kim Jin-Kyu
Bae Young-Soo
Won Moo-Ho
Kang Il-Jun
Lim Soon-Sung
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Abstract
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A flavanol glycoside, glucodistylin (1) and three polyphenol derivatives, gallate (2), (+)-catechin (3) and (+)-gallocatechin (4) were isolated from an aqueous acetone extract of the bark of Quercus acutissima. Of these compounds, glucodistylin exhibited uncompetitive inhibitory activity against recombinant human aldose reductase with an IC50 value of 7.2 μM. Furthermore, glucodistylin inhibited sorbitol accumulation by 48.84% at 50 μM. This flavonoid showed therapeutic potential in the prevention and treatment of diabetes-related complications.
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KEYWORD
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Glucodistylin, Recombinant human aldose reductase, Sorbitol, Diabetes-related, complications
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